Deadline: 1 December 2022

HSE has received several applications for authorisation for the following substances/uses:

• Reference: AFA018-01
  Substance: 4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated (4-tert-OPnEO)
  Use: Use of IVD kit reagents on diagnostic analyser systems by professional users
  View the consultation details
  
  
• Reference: AFA018-02
  Substance: 4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated (4-tert-OPnEO)
  Use: Use of IVD wash solutions on diagnostic analyser systems by professional users
  View the consultation details
  
  
• Reference: AFA020-01
  Substance: 4-(1,1,3,3 tetramethylbutyl)phenol, ethoxylated (4-tert-OPnEO)
  Use: Professional use as a surfactant, in Wash Buffer components used in conjunction with Fluorescence in Situ Hybridisation (FISH) test kits and/or their Laboratory Developed Test (LDT) equivalents, in clinical diagnostic use for medical analysis of human tissue and blood samples to identify characteristic genetic abnormalities related to specific disease conditions
  View the consultation details
  
  
• Reference: AFA021-01
  Substance: 4-(1,1,3,3 tetramethylbutyl)phenol, ethoxylated (4-tert-OPnEO)
  Use: Use of 4-(1,1,3,3 tetramethylbutyl)phenol, ethoxylated (4-tert-OPnEO) for the lysis of different types of cells in order to release the cell contents for subsequence analysis in diagnostics
  View the consultation details
  
  
• Reference: AFA024-01
  Substance: Chromium trioxide
  Use: Industrial use of chromium trioxide for the decorative chromium electroplating of legacy components
  View the consultation details
  
  
• Reference: AFA025-01
  Substance: Chromium trioxide
  Use: Industrial use of chromium trioxide for the chromium electroplating of sanitaryware and plumbing components
  View the consultation details
  
  
• Reference: AFA026-01
  Substance: Chromium trioxide
  Use: Industrial use of chromium trioxide for the functional chromium electroplating of technical components
  View the consultation details

Article 64 in the UK REACH Regulation makes provisions for HSE to obtain and use additional information on possible alternatives or technologies as part of the opinion forming process.

HSE has announced public consultations for each of these applications. Details can be viewed at the links above.

Any third parties with an interest in these applications are strongly encouraged to share any relevant information.

Scientific and technical information on possible alternatives or technologies should be submitted directly to HSE using the commenting webform and templates by 1 December 2022.

Non-confidential comments will be published on HSE's website.

Visit the HSE website for details of adopted opinions, granted UK REACH authorisations and in-progress applications.