Scientists at Aberystwyth University are leading research into how a widely used vaccine can boost overall immunity in livestock. The four-year study will investigate the concept of ‘trained immunity’ – a form of immune memory triggered by a vaccine, which reprogrammes the immune system to respond more effectively to future unrelated infections.

The research team will study the impact of the BCG vaccine, which is hoped to be used to help control tuberculosis in cattle, and has been demonstrated to trigger trained immunity.

Using advanced lab techniques and cattle tissue samples, the team will study the molecular mechanisms that lead to trained immunity in vaccinated livestock.

The study could lead to healthier livestock, reduced reliance on antibiotics, and lower environmental impacts from farming.

Dr Amanda Gibson, Lecturer in Innate Immunology at the Sêr Cymru Centre of Excellence for Bovine Tuberculosis, is leading the research. She said:
“This is a fantastic opportunity to explore the potential of trained immunity in livestock and to contribute to the development of more sustainable and resilient farming systems. I’m excited to work with colleagues across disciplines and sectors to deliver research that can make a real-world impact on animal health and environmental sustainability.”

Professor Iain Barber, Pro Vice-Chancellor of the Faculty of Sciences at Aberystwyth University, said:
“Dr Gibson’s work addresses some of the most pressing challenges in animal health and sustainable agriculture. We are proud to support her as she leads this exciting and impactful programme, which reflects the world-class research taking place here in Aberystwyth.”

Dr Gibson will collaborate with partners including the Animal and Plant Health Agency (APHA), the Office of the Chief Veterinary Officer for Wales, Arwain DGC (Defnydd Gwrthficrobaidd Cyfrifol/Responsible Antimicrobial Use), and the Roslin Institute.

Dr Camille Harrison, lead scientist for bovine tuberculosis at APHA, said:
“I look forward to working more closely with Dr Amanda Gibson and her team to develop collaborative projects that support TB eradication efforts and deepen our understanding of immunological pathways.”

The work is supported by a UK Research and Innovation (UKRI) Future Leaders Fellowship, awarded to Dr Gibson in recognition of her leadership in the field of immunology and animal health.

UKRI Chief Executive, Professor Sir Ian Chapman, said:
“UKRI’s Future Leaders Fellowships offer long-term support to outstanding researchers, helping them turn bold ideas into innovations that improve lives and livelihoods in the UK and beyond.

“These fellowships continue to drive excellence and accelerate the journey from discovery to public benefit. I wish them every success.”
Dr Gibson joined Aberystwyth University in 2020 from the Royal Veterinary College, London, where she established the innate immunology group. She holds a BSc (Hons) in Immunology from the University of Glasgow and a PhD in Molecular Immunology from the University of London. Her career spans industry (Philips Healthcare), the civil service (Health Protection Agency, now UKHSA), and academia.